Insulin signaling requires glucose to promote lipid anabolism in adipocytes
James R. Krycer, Lake‐Ee Quek, Deanne Francis, Armella Zadoorian, Fiona Weiss, Kristen C. Cooke, Marin E. Nelson, Alexis Díaz‐Vegas, Sean J. Humphrey, R. Scalzo, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Kevin Huynh, Corey Giles, Bianca Varney, Shilpa R. Nagarajan, Andrew J. Hoy, Tomoyoshi Soga, Peter J. Meikle, Gregory J. Cooney, Daniel J. Fazakerley, David E. James
Abstract
Together, these data highlight the importance of glucose metabolism to support insulin action, providing a complementary regulatory mechanism to signal transduction to stimulate adipose anabolism.
Topics & Concepts
LipogenesisInsulinAnabolismGlucose uptakeInternal medicineInsulin receptorLipolysisEndocrinologyCarbohydrate metabolismBiologyGlucose homeostasisAdipose tissueAdipocyteLipid metabolismBiochemistryChemistryInsulin resistanceMedicineAdipose Tissue and MetabolismLipid metabolism and biosynthesisNeurobiology and Insect Physiology Research