AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases
Heyu Li, Chao Liu, Ran Li, Lili Zhou, Yu Ran, Qiqing Yang, Huizhe Huang, Huasong Lu, Hai Song, Bing Yang, Heng Ru, Shixian Lin, Long Zhang
Topics & Concepts
LysineSense (electronics)ChemistryBiochemistryCell biologyBiologyAmino acidPhysical chemistryinterferon and immune responsesRNA modifications and cancerUbiquitin and proteasome pathways