Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors
Ryan T. Howard, Paul Hemsley, Philip Petteruti, Charlie N. Saunders, Javier A. Molina Bermejo, James S. Scott, Jeffrey W. Johannes, Edward W. Tate
Abstract
provides a new approach to expand our knowledge of the targets of this class of compounds and the mechanisms of action of PARP inhibitors in cancer.
Topics & Concepts
OlaparibPoly ADP ribose polymerasePARP1PARP inhibitorEnzymePolymeraseComputational biologyRecombinant DNABiologyCancer cellChemical biologyCell biologyCellBiochemistryChemistryCancer researchCancerGeneticsGenePARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisToxin Mechanisms and Immunotoxins