Design, synthesis, and biological evaluation of β-carboline 1,3,4-oxadiazole based hybrids as HDAC inhibitors with potential antitumor effects
Caizhi Tian, Shuoqi Huang, Zihua Xu, Wenwu Liu, Deping Li, Mingyue Liu, Chengze Zhu, Limeng Wu, Xiaowen Jiang, Huaiwei Ding, Qingchun Zhao
Topics & Concepts
ChemistryCytotoxicityADMEOxadiazoleIC50ApoptosisIn vitroBiochemistryStereochemistryPharmacologyBiologyOrganic chemistryHistone Deacetylase Inhibitors ResearchCholinesterase and Neurodegenerative DiseasesSynthesis and bioactivity of alkaloids