Rapamycin maintains NAD+/NADH redox homeostasis in muscle cells
Zhigang Zhang, He N. Xu, Siyu Li, Antonio Dávila, Karthikeyani Chellappa, James G. Davis, Yuxia Guan, David W. Frederick, Weiqing Chu, Huaqing Zhao, Lin Z. Li, Joseph A. Baur
Abstract
-dependent enzymes. This study provides new insight into the mechanisms by which rapamycin might influence the aging process to improve health and longevity among the aging population.
Topics & Concepts
NAD+ kinaseRedoxNicotinamide phosphoribosyltransferaseCell biologyBiologyBiochemistryMyogenesisMyocyteMetabolismC2C12ChemistryEnzymeOrganic chemistryMuscle Physiology and DisordersGenetics, Aging, and Longevity in Model OrganismsCoenzyme Q10 studies and effects