One-Pot Regioselective Synthesis of Some Novel Isoxazole-Phenothiazine Hybrids and Their Antibacterial Activity
Veeranna Guguloth, Narasimha Swamy Thirukovela, S. Paidakula, Ravinder Vadde
Abstract
Abstract Some novel isoxazole-phenothiazine hybrids have been synthesized regioselectively in high yields via Cu(I) catalyzed one-pot reaction of 10-(prop-2-yn-1-yl)phenothiazine with aromatic aldehydes in aqueous butanol medium. Structures of the newly phenothiazine-isoxazole compounds have been confirmed by 1H and 13C NMR, and mass spectral data. Products have been evaluated for their antibacterial activity, and few of those demonstrate high growth inhibition activity as compared against the standards drugs Penicillin-G and Streptomycin.
Topics & Concepts
IsoxazolePhenothiazineChemistryAntibacterial activityRegioselectivityCombinatorial chemistryOrganic chemistryStereochemistryCatalysisBacteriaPharmacologyMedicineGeneticsBiologyPhenothiazines and Benzothiazines Synthesis and ActivitiesQuinazolinone synthesis and applicationsSynthesis and biological activity