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The nickel-sirohydrochlorin formation mechanism of the ancestral class II chelatase CfbA in coenzyme F430 biosynthesis

Takashi Fujishiro, S.Y. Ogawa

2021Chemical Science10 citationsDOIOpen Access PDF

Abstract

The substrate-assisted nickel chelatase mechanism of CfbA in coenzyme F430 biosynthesis was unveiled by X-ray crystal structure analysis.

Topics & Concepts

BiosynthesisMechanism (biology)CofactorNickelChemistryStereochemistryEnzymeSubstrate (aquarium)BiochemistryBiologyEcologyOrganic chemistryPhilosophyEpistemologyPhotosynthetic Processes and MechanismsMicrobial Community Ecology and PhysiologyGenomics and Phylogenetic Studies
The nickel-sirohydrochlorin formation mechanism of the ancestral class II chelatase CfbA in coenzyme F430 biosynthesis | Litcius