N-heterocyclic carbene-catalyzed direct enantioselective synthesis of dihydroisoxazolo[5,4-<i>b</i>]pyridin-6-ones
Xiaoxia Huang, Yarui Li, Jieyin He, Shiyong Peng, Jian Wang, Ming Lang
Abstract
A novel N-heterocyclic carbene (NHC)-catalyzed asymmetric [3 + 3] cycloaddition between α-bromoenals and 5-aminoisoxazoles has been developed.
Topics & Concepts
CarbeneChemistryEnantioselective synthesisCatalysisCycloadditionCombinatorial chemistryMedicinal chemistryOrganic chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods