Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis
Xiangyu Li, Yufei Hou, Xiangxue Meng, Ge Li, Fei Xu, Lesheng Teng, Fengying Sun, Youxin Li
Abstract
increased markedly under 808 nm laser irradiation. In a cellular uptake study, stronger fluorescence signals were observed in activated macrophages when treated with FAGMs, suggesting that folic acid molecules enabled the enhancement of endocytosis into activated macrophages. In rats with adjuvant-induced arthritis, synergistic treatment excellently inhibited the progression of RA. These results demonstrated that FAGMs could be promising for the treatment of RA.
Topics & Concepts
Photothermal therapyFolate receptorMesoporous silicaRheumatoid arthritisMethotrexateZeta potentialPhotothermal effectChemotherapyChemistryBiophysicsHyperthermiaIn vitroNanorodNanoparticleCancer researchMaterials scienceNanotechnologyCancer cellCancerMesoporous materialImmunologyMedicineBiochemistryInternal medicineCatalysisBiologyExtracellular vesicles in diseaseAutoimmune and Inflammatory Disorders ResearchSystemic Lupus Erythematosus Research