Formulating monoclonal antibodies as powders for reconstitution at high concentration using spray-drying: Trehalose/amino acid combinations as reconstitution time reducing and stability improving formulations
Jan Massant, Sabrina Fleurime, Maarten Batens, Heline Vanhaerents, Guy Van den Mooter
Topics & Concepts
TrehaloseFreeze-dryingSpray dryingChemistrySucroseAmino acidSugarChromatographyReducing sugarBiochemistryProtein purification and stabilityTransgenic Plants and ApplicationsMicroencapsulation and Drying Processes