Pin1 inhibitor API-1 sensitizes BRAF-mutant thyroid cancers to BRAF inhibitors by attenuating HER3-mediated feedback activation of MAPK/ERK and PI3K/AKT pathways
Hui Dang, Mengjun Sui, Qingyuan He, Jingyi Xie, Yan Liu, Peng Hou, Meiju Ji
Topics & Concepts
MAPK/ERK pathwayCancer researchPI3K/AKT/mTOR pathwayProtein kinase BThyroid cancerCancerChemistryPIN1ApoptosisSignal transductionBiologyMedicineInternal medicineBiochemistryEnzymeIsomeraseSignaling Pathways in DiseaseCancer Mechanisms and TherapyCell death mechanisms and regulation