Novel 4-Oxoquinazoline-Based<i>N</i>-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation
Duong Tien Anh, Hai Pham‐The, Le D. Huy, Hoàng Bảo Ngọc, Trinh T. M. Ngoc, Đỗ Thị Mai Dung, Eun Jeong Park, In K. Song, Jong Soon Kang, Joo‐Hee Kwon, Trương Thanh Tùng, Sang‐Bae Han, Nguyen‐Hai Nam
Abstract
and revealed some important features contributing to the inhibitory activity of synthesized compounds.
Topics & Concepts
CytotoxicityHistone deacetylaseChemistryStereochemistryDocking (animal)IC50HDAC8MoietyInhibitory postsynaptic potentialVorinostatHDAC1BiochemistryHistoneIn vitroBiologyMedicineNursingGeneNeuroscienceHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisSynthetic Organic Chemistry Methods