A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood
Maya Sangesland, Ashraf S. Yousif, Larance Ronsard, Samuel W. Kazer, Alex Zhu, G. James Gatter, Matthew R. Hayward, Ralston M. Barnes, Maricel Quirindongo-Crespo, Daniel Rohrer, Nils Lönberg, Douglas S. Kwon, Alex K. Shalek, Daniel Lingwood
Abstract
-gene-dependent responses are directed against the non-variable and universal saccrolipid substructure of this antigen. This reveals a broad-spectrum anti-LPS response in which germline-encoded CDRs naturally hardwire the human antibody repertoire for recognition of a conserved microbial target.
Topics & Concepts
Complementarity determining regionAntibody RepertoireBiologyGeneAntibodyPolyclonal antibodiesAntigenImmune systemGeneticsGermlineComputational biologyMonoclonal antibodyMonoclonal and Polyclonal Antibodies ResearchT-cell and B-cell ImmunologyRNA and protein synthesis mechanisms