Fluorescent Ensemble Sensors and Arrays Based on Surfactant Aggregates Encapsulating Pyrene-Derived Fluorophores for Differentiation Applications
Min Qiao, Junmei Fan, Liping Ding, Yu Fang
Abstract
Surfactant assemblies have drawn great attention in fabricating fluorescent sensors as they can provide advantages such as easy preparation, low cost, aqueous detection, high fluorescence stability, high sensitivity to external stimuli, etc. We have devoted the past few years to fluorescent cross-reactive sensors and arrays that are advantageous in differentiating similar analytes and analyzing mixed samples. In this Spotlight on Applications, we introduce our recent advances in developing surfactant assembly-based fluorescent sensors and arrays for discrimination applications. Besides using surfactant assemblies encapsulating fluorophores to fabricate multiple-element-based sensor arrays, we particularly proposed to take advantage of modulation effect of dynamic surfactant assemblies on the photophysical properties of encapsulated fluorophores to construct single-system-based discriminative sensors, which have been successfully applied in differentiation of multiple metal ions and various proteins. The applications of surfactant assembly-based sensors for the detection and discrimination of thiols, amino acids, and explosives are also introduced. Finally, the prospects of further efforts for improving surfactant ensemble sensors and their challenges are discussed.