Electrochemical heterodifunctionalization of α-CF<sub>3</sub>alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols
Zhipeng Ye, Jie Gao, Xinyu Duan, Jianping Guan, Fang Liu, Kai Chen, Jun‐An Xiao, Hao‐Yue Xiang, Hua Yang
Abstract
alkenes with benzenesulfonyl hydrazides was accomplished in this work, wherein a β-sulfonyl and a α-hydroxyl group were simultaneously incorporated across the olefinic double bond in a single operation. Consequently, a series of potentially medicinally valuable and densely functionalized α-trifluoromethyl-β-sulfonyl tertiary alcohols were assembled under mild conditions. Electrochemically-driven oxidative 1,2-difunctionlization of electron-deficient alkenes well obviates the need for oxidizing reagents, thus rendering this protocol more eco-friendly.
Topics & Concepts
SulfonylTrifluoromethylOxidizing agentChemistryReagentTertiary alcoholsElectrochemistryAlkeneTrifluoromethylationOrganic chemistryCombinatorial chemistryCatalysisAlkylPhysical chemistryElectrodeFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesRadical Photochemical Reactions