Saikosaponins from Bupleurum scorzonerifolium Willd. alleviates microglial pyroptosis in depression by binding and inhibiting P2X7 expression
Yu Bi, Mengmeng Li, Yue Wang, Jun Yao, Yuxuan Wang, Siyi Wang, Leixin Zhuang, Shuang Liu, Ziwei Li, Zhichao Hao, Wei Guan, Juan Pan, Peng Jiang, Yiqiang Zhang, Haixue Kuang, Qingshan Chen, Lili Zhang, Bing‐You Yang, Yan Liu, Yan Liu
Topics & Concepts
PyroptosisBupleurumMicrogliaTraditional medicineDepression (economics)ChemistryMedicinePharmacologyBiologyBiochemistryApoptosisImmunologyProgrammed cell deathPathologyInflammationTraditional Chinese medicineMacroeconomicsEconomicsAlternative medicineTryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsNatural product bioactivities and synthesis