Visualization of endogenous p27 and Ki67 reveals the importance of a c-Myc-driven metabolic switch in promoting survival of quiescent cancer cells
Ting La, Song Chen, Tao Guo, Xiao Hong Zhao, Teng Liu, Dandan Li, Michael Carnell, Yuan Yuan Zhang, Yuchen Feng, Nicole Cole, Alexandra C. Brown, Didi Zhang, Qihan Dong, Jenny Wang, Huixia Cao, Tao Liu, Rick F. Thorne, Feng-Min Shao, Xu Dong Zhang, Lei Jin
Abstract
These results establish a rigorous experimental system for investigating cellular quiescence, uncover the high selectivity of c-Myc in activating OXPHOS genes in quiescent cells, and propose OXPHOS targeting as a potential therapeutic avenue to counter cancer cells in quiescence.
Topics & Concepts
BiologyCancer cellCell cycleCell biologyContext (archaeology)CellCancer researchCancerBiochemistryGeneticsPaleontologyCancer-related Molecular PathwaysVirus-based gene therapy researchCancer Research and Treatments