Response to PARP Inhibition in <i>BARD1</i> -Mutated Refractory Neuroblastoma
Margaret Cupit-Link, Kohei Hagiwara, Matthew Nagy, Selene C. Koo, Brent A. Orr, Eytan Ruppin, John Easton, Jinghui Zhang, Sara M. Federico
Abstract
Some neuroblastomas carry disabling mutations in BARD1 , a homologous recombination repair gene. A child with refractory neuroblastoma and a BARD1 mutation had a sustained response after treatment with the PARP inhibitor talazoparib.
Topics & Concepts
Refractory (planetary science)Poly ADP ribose polymeraseCancer researchNeuroblastomaChemistryBiologyGeneticsDNACell cultureAstrobiologyPolymeraseNeuroblastoma Research and TreatmentsPARP inhibition in cancer therapyCardiac electrophysiology and arrhythmias