Enantioconvergent Reductive C(sp)−C(sp<sup>3</sup>) Cross‐Coupling to Access Chiral α‐Alkynyl Phosphonates Under Dual Nickel/Photoredox Catalysis
Hepan Wang, Xiaoqiang Wu, Tao Xu
Abstract
Abstract Transition‐metal‐catalyzed asymmetric carbon−carbon bond formation to forge phosphonates with an α‐chiral carbon center through C(sp 3 )−C(sp 3 ) and C(sp 2 )−C(sp 3 ) couplings has been successful. However, the enantioselective C(sp)−C(sp 3 ) coupling has not yet been disclosed. Reported herein is an unprecedented enantioconvergent cross‐coupling of alkynyl bromides and α‐bromo phosphonates to deliver chiral α‐alkynyl phosphonates.
Topics & Concepts
CatalysisChemistryEnantioselective synthesisNickelTransition metalAsymmetric carbonCarbon fibersCoupling (piping)Combinatorial chemistryMedicinal chemistryMetalStereochemistryOrganic chemistryOptically activeMaterials scienceComposite numberComposite materialMetallurgyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques