FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy
Jia Wang, Jian Sha, Emily Strong, Ashok K. Chopra, Sunhee Lee
Abstract
The emergence and spread of multidrug-resistant (MDR) and extensive drug-resistant (XDR) TB urges the development of new therapeutics. One promising approach to combat drug resistance is targeting host factors necessary for the bacteria to survive or replicate while simultaneously minimizing the dosage of traditional agents.
Topics & Concepts
AutophagyIntracellularMycobacterium tuberculosisIntracellular parasiteCytotoxicityMacrophageMicrobiologyBiologyMycobacteriumMycobacterium bovisTuberculosisCell biologyMedicineApoptosisIn vitroBiochemistryBacteriaGeneticsPathologyAutophagy in Disease and TherapyHIV Research and TreatmentTuberculosis Research and Epidemiology