Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification
Daniela Carbone, Vincenzo Vestuto, Maria Rosalia Ferraro, Tania Ciaglia, Camilla Pecoraro, Eduardo Sommella, Stella Cascioferro, Emanuela Salviati, Sara Novi, Mario Felice Tecce, Giuseppina Amodio, Nunzio Iraci, Girolamo Cirrincione, Pietro Campiglia, Patrizia Diana, Alessia Bertamino, Barbara Parrino, Carmine Ostacolo
Topics & Concepts
Drug discoveryMetabolomicsComputational biologyChemistryPhenotypic screeningPharmacologyIC50PhenotypeBiologyBioinformaticsBiochemistryIn vitroGeneCancer, Hypoxia, and MetabolismMetabolomics and Mass Spectrometry StudiesBiochemical and Molecular Research