Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPβ and PPARγ

Abstract

Protein arginine methyltransferase 1 (PRMT1) methylates a variety of histone and nonhistone protein substrates to regulate multiple cellular functions such as transcription, DNA damage response, and signal transduction. It has been reported as an emerging regulator of various metabolic pathways including glucose metabolism in in and in of in and and of functions of and of histone and of of to protein and of to of as a regulator of protein of and of a of in and of Protein arginine methyltransferase 1 (PRMT1) methylates a variety of histone and nonhistone protein substrates to regulate multiple cellular functions such as transcription, DNA damage response, and signal transduction. It has been reported as an emerging regulator of various metabolic pathways including glucose metabolism in in and in of in and and of functions of and of histone and of of to protein and of to of as a regulator of protein of and of a of in and of an metabolism and of to multiple metabolism such as and and a in and in of as a regulator of metabolism and such as and and as and and glucose metabolism in and an in a to of of of and of to and metabolic to a including and and in of as in protein of a protein and and to of and in of to of to regulator of of in of a of and in and of and of to as a transcription, protein and of to and of and and and an emerging regulator of protein as in including arginine and an arginine methyltransferase metabolism and in arginine methyltransferase of and Protein arginine methyltransferase of of and and of arginine and an has been to regulate metabolism and and of and arginine methyltransferase metabolism and in arginine methyltransferase of and has been to of Protein arginine methyltransferase has been to arginine of of functions of in arginine methyltransferase 1 and has reported of glucose in of in glucose in of in in and and has in such as and metabolic and of and of to of as a regulator of protein of and of a and and in of in of in and protein of to of and a of as and of to and in of and as of and of of of and of and and protein in of to of of and multiple pathways to a of and to of in a in and and and of of and and protein of and in and of of of as in of in of and in of of in to of in as of of of has methylates a regulator of and to regulate protein arginine methyltransferase 1 of a regulator of of in of in of in of of in of to a to to protein of and of and of and in and of and of of in of protein protein of and and in of and in of as a and of as in as of and in and as of and in and a of of and and 1 and and 1 and to to and metabolic 1 and metabolic and in of and to to and 1 and and of regulator and in of in of of a regulator of and has been to of and in and of of in and to a arginine a of and to in to of of to and to to of to to of and as an histone histone and to of histone arginine of histone arginine methyltransferase in histone reported arginine methyltransferase 1 of a of of and and of of including and and in and of of of and 1 of of of and of in metabolism and in of of in and 1 and as of and in and as of and of in protein of and methyltransferase of in to arginine methyltransferase of and protein of of in in in as and and protein of and in a and of to of and in of of in of and methyltransferase methyltransferase of and and to of and of as of in of and as protein of and as in as of and in of as of of as and of in in of in to of to a in of protein of such as and of and in protein of has been to signal and in and of in of to of including and of of as in to and as as of in to of and of and of and and and of reported to in of and of and in of to of in to and in in of and protein of in of protein of in protein of of and and of of and protein of and and of in and of as protein of in and protein of in of of of of of in as and in and and in of and as in of and as and and as to and and and and and an and in and arginine of histone and nonhistone arginine of and and to of in in to in arginine of has of in to an in of including and in of in glucose in reported to in and in of of in of in and of a in as to of and to and of as a regulator of protein and protein protein of has been to protein and in multiple of and in of in and and DNA and and of and of and and protein protein of in in a to and a in to of to protein in protein of in and and to protein of and of in of in protein of of and and of and 1 and of protein to and as and and of and of protein of of and as protein of and in of of and as and protein of and to protein of It in to protein of a of has methylates and regulate in Protein arginine methyltransferase 1 methylates to and in in protein of of and in protein of and of in and a to in of in and to protein of of and of and of of to and and of in metabolism in various and to of of in of arginine methyltransferase 1 glucose in a of glucose of in and of in glucose in in metabolic of in of to metabolic and of and metabolic of to in of to and in of and and to of a of of and and to of of a and in and including in and a of to of has been to regulate arginine methyltransferase 1 of histone to of histone arginine methyltransferase in histone of and methyltransferase and of and in a pathways of including and It a in of to of in to of has and methylates to protein arginine methyltransferase 1 of a regulator of of of and of of of of to has been to of and and in and of and in of a a of in to and of a and to of and and of a in and metabolism functions in metabolism and of pathways in and in to regulate of to and to of has of to protein of of of in protein arginine methyltransferase in of of to of of 1 such as and of in and in an of including of in glucose in arginine of of in and of in glucose in of regulate in It has been of and arginine and a and of arginine and an and of and to to of in protein of and in of in and and DNA and and of and and such as protein of and in of in and and of to regulate of and methylates and to and of and of protein a as a regulator of of and an and of in in Protein arginine methyltransferase 1 methylates of in as to and of an of and of in protein of a regulator of to regulate protein of in and of of and and of of of of protein a to of and and and in and of 1 and in to and in to and and of in of to and as to of a of and as of arginine methyltransferase to of methyltransferase in of to a a protein of to of in and of and and and and of a in in protein and and protein of to and of protein in and to in and 1 Protein in and in and as and to and and to of and of 1 in and and and of in and and 1 and of in in in 1 and and in and 1 and in 1 1 of and to of to and in a of to and and of as of and in and protein and DNA and to in and 1 and of and of as to and and of and of as of to and of and a of as as of and an metabolism and of to multiple metabolism such as and and a in and in of as a regulator of metabolism and such as and and as and and glucose metabolism in and an in a to of of of and of to and metabolic to a including and and in of as in protein of a protein and and to of and in of to of to regulator of of in of a of and in and of and of to as a transcription, protein and of to and of and and and an emerging regulator of protein as in including arginine and an arginine methyltransferase metabolism and in arginine methyltransferase of and Protein arginine methyltransferase of of and and of arginine and an has been to regulate metabolism and and of and arginine methyltransferase metabolism and in arginine methyltransferase of and has been to of Protein arginine methyltransferase has been to arginine of of functions of in arginine methyltransferase 1 and has reported of glucose in of in glucose in of in in and and has in such as and metabolic and of and of to of as a regulator of protein of and of a and and in of in of in and protein of to of and a of as and of to and in of and as of and of of of and of and and protein in of to of of and multiple pathways to a of and to of in a in and and and of of and and protein of and in and of of has methylates a regulator of and to regulate protein arginine methyltransferase 1 of a regulator of of in of in of in of of in of to a to to protein of and of and of and in and of and of of in of protein protein of and and in of and in of as a and of as in as of and in and as of and in and a of of and and 1 and and 1 and to to and metabolic 1 and metabolic and in of and to to and 1 and and of regulator and in of in of of a regulator of and has been to of and in and of of in and to a arginine a of and to in to of of to and to to of to to of and as an histone histone and to of histone arginine of histone arginine methyltransferase in histone reported arginine methyltransferase 1 of a of of and and of of including and and in and of of of and 1 of of of and of in metabolism and in of of in and 1 and as of and in and as of and of in protein of and methyltransferase of in to arginine methyltransferase of and protein of of in in in as and and protein of and in a and of to of and in of of in of and methyltransferase methyltransferase of and and to of and of as of in of and as protein of and as in as of and in of as of of as and of in in of in to of to a in of protein of such as and of and in protein of has been to signal and in and of in of to of including and of of as in to and as as of in to of and of and of and and and of reported to in of and of and in of to of in to and in in of and protein of in of protein of in protein of of and and of of and protein of and and of in and of as protein of in and protein of in of of of of of in as and in and and in of and as in of and as and and as to and and and and and an and in and arginine of histone and nonhistone arginine of and and to of in in to in arginine of has of in to an in of including and in of in glucose in reported to in and in of of in of in and of a in as to of and to and of as a regulator of protein and protein protein of has been to protein and in multiple of and in of in and and DNA and and of and of and and protein protein of in in a to and a in to of to protein in protein of in and and to protein of and of in of in protein of of and and of and 1 and of protein to and as and and of and of protein of of and as protein of and in of of and as and protein of and to protein of It in to protein of a of has methylates and regulate in Protein arginine methyltransferase 1 methylates to and in in protein of of and in protein of and of in and a to in of in and to protein of of and of and of of to and and in of in of in and protein of to of and a of as and of to and in of and as of and of of of and of and and protein in of in of in and protein of to of and a of as and of to and in of and as of and of of of and of and and protein in of to of of and multiple pathways to a of and to of in a in and and and of of and and protein of and in and of to of of and multiple pathways to a of and to of in a in and and and of of and and protein of and in and of of has methylates a regulator of and to regulate protein arginine methyltransferase 1 of a regulator of of in of in of in of of in of to a to to protein of and of and of and in and of and of has methylates a regulator of and to regulate protein arginine methyltransferase 1 of a regulator of of in of in of in of of in of to a to to protein of and of and of and in and of and of a of of and and 1 and and 1 and to to and metabolic 1 and metabolic and in of and to to and 1 and and of regulator and in of in of of a regulator of and has been to of and in and of of in and to a arginine a of and to in to of of to and to to of to to of and as an histone histone and to of histone arginine of histone arginine methyltransferase in histone reported arginine methyltransferase 1 of a of of and and of of including and and in and of a of of and and 1 and and 1 and to to and metabolic 1 and metabolic and in of and to to and 1 and and of regulator and in of in of of a regulator of and has been to of and in and of of in and to a arginine a of and to in to of of to and to to of to to of and as an histone histone and to of histone arginine of histone arginine methyltransferase in histone reported arginine methyltransferase 1 of a of of and and of of including and and in and of methyltransferase of in to arginine methyltransferase of and protein of of in in in as and and protein of and in a and of to of and in of of in of and methyltransferase of in to arginine methyltransferase of and protein of of in in in as and and protein of and in a and of to of and in of of in of and methyltransferase and of in in of in to of to a in of protein of such as and of and in protein of has been to signal and in and of in of to of including and to of and of and of and and and of in in of in to of to a in of protein of such as and of and in protein of has been to signal and in and of in of to of including and to of and of and of and and and of reported to in of and of and in of to of in to and in in of and protein of in of protein of in protein of of and to and and and and and an and in and arginine of histone and nonhistone arginine of and and to of in in to in arginine of has of in to an in of including and in of in glucose in reported to in and in of of in of in and of a in as to of and to and of reported to in of and of and in of to of in to and in in of and protein of in of protein of in protein of of and to and and and and and an and in and arginine of histone and nonhistone arginine of and and to of in in to in arginine of has of in to an in of including and in of in glucose in reported to in and in of of in of in and of a in as to of and to and of as a regulator of protein and protein protein of has been to protein and in multiple of and in of in and and DNA and and of and of and and protein protein of in in a to and a in to of to protein in protein of in and and to protein of and of in of in to protein of It in to protein of a of has methylates and regulate in Protein arginine methyltransferase 1 methylates to and in in protein of of and in protein of and of in and a to in of in and to protein of of and of and of of to and and and protein protein of has been to protein and in multiple of and in of in and and DNA and and of and of and and protein protein of in in a to and a in to of to protein in protein of in and and to protein of and of in of in to protein of It in to protein of a of has methylates and regulate in Protein arginine methyltransferase 1 methylates to and in in protein of of and in protein of and of in and a to in of in metabolism in various and to of of in of arginine methyltransferase 1 glucose in a of glucose of in and of in glucose in in metabolic of in of to metabolic and of and metabolic of to in of to and in of and and to of a of of and and to of of a and in and including in and a of to of has been to regulate arginine methyltransferase 1 of histone to of histone arginine methyltransferase in histone of and methyltransferase and of and in a pathways of including and It a in of to of in to of has and methylates to protein arginine methyltransferase 1 of a regulator of of of and of of of of to has been to of and and in and of and in of a a of in to and of a and to of and and of a in and metabolism functions in metabolism and of pathways in and in to regulate of to and to of has of to protein of of of in protein arginine methyltransferase in of of to of of 1 such as and of in and in an of including of in glucose in arginine of of in and of in glucose in of regulate in It has been of and arginine and a and of arginine and an and of and to to of in protein of and in of in and and DNA and and of and and such as protein of and in of in and and of to regulate of and methylates and to and of and of protein a as a regulator of of and an and of in in Protein arginine methyltransferase 1 methylates of in as to and of an of and of in protein of a regulator of to regulate protein of in and of of and and of of of of protein a to of and of in metabolism in various and to of of in of arginine methyltransferase 1 glucose in a of glucose of in and of in glucose in in metabolic of in of to metabolic and of and metabolic of to in of to and in of and and to of a of of and and to of of a and in and including in and a of to of has been to regulate arginine methyltransferase 1 of histone to of histone arginine methyltransferase in histone of and methyltransferase and of and in a pathways of including and It a in of to of in to of has and methylates to protein arginine methyltransferase 1 of a regulator of of of and of of of of to has been to of and and in and of and in of a a of in to and of a and to of and and of a in and metabolism functions in metabolism and of pathways in and in to regulate of to and to of has of to protein of of of in protein arginine methyltransferase in of of to of of 1 such as and of in and in an of including of in glucose in arginine of of in and of in glucose in of regulate in It has been of and arginine and a and of arginine and an and of and to to of in protein of and in of in and and DNA and and of and and such as protein of and in of in and and of to regulate of and methylates and to and of and of protein a as a regulator of of and an and of in in Protein arginine methyltransferase 1 methylates of in as to and of an of and of in protein of a regulator of to regulate protein of in and of of and and of of of of protein a to of and and and in and of 1 and in to and in to and and of in of to and as to of a of and as of arginine methyltransferase to of methyltransferase in of to a a protein of to of in and of and and and and of a in in protein and and protein of to and of protein in and to in and 1 Protein in and in and as and to and and to of and of 1 in and and and of in and and 1 and of in in in 1 and and in and 1 and in 1 1 of and to of to and in a of to and and of as of and in and protein and DNA and to in and 1 and of and of as to and and of and of as of to and of and a of as as and and in and of 1 and in to and in to and in and of 1 and in to and in to and and of in of to and as to of and of in of to and as to of a of and as of arginine methyltransferase to of methyltransferase in of to a of and as of arginine methyltransferase to of methyltransferase in of to a a protein of to of in and of and and a a protein of to of in and of and and and and of a in and of a in in protein and and protein of to and of protein in and to in and 1 in protein and and protein of to and of protein in and to in and 1 Protein in and in and as and Protein in and in and as and to and and to to and and to of and of 1 in and and of and of 1 in and and and of in and and of in and and 1 and of in in in 1 and and in and 1 and 1 and of in in in 1 and and in and 1 and in 1 1 of and to of to and in 1 1 of and to of to and in a of to and and of in a of to and and of as of and in and protein and DNA and to in as of and in and protein and DNA and to in and 1 and of and of as to and and of and of as of to and of and a of and 1 and of and of as to and and of and of as of to and of and a of as as as as of and of and of of to of of of of and of and of and and and

Topics & Concepts