Iterative Convergent Synthesis of Large Cyclic Polymers and Block Copolymers with Discrete Molecular Weights
Mo Beom Koo, Seul Woo Lee, Jung Min Lee, Kyoung Taek Kim
Abstract
-lactide) (PLA) and its block copolymers with as many as 512 lactic acid units (37 kDa), synthesized by the iterative linear convergence of orthogonally protected building blocks. By exploiting the change in hydrodynamic volume upon cyclization of the linear polymers, macrocyclic polymers were isolated without linear precursors by preparative size-exclusion chromatography as a purification method. Our procedure also allowed the synthesis of a monodisperse cyclic block copolymer in a desired block ratio as a single compound (14 kDa).
Topics & Concepts
CopolymerChemistryDispersityPolymerBlock (permutation group theory)Linear polymerPolymer chemistrySize-exclusion chromatographyCombinatorial chemistryOrganic chemistryMathematicsEnzymeGeometrybiodegradable polymer synthesis and propertiesAdvanced Polymer Synthesis and CharacterizationSynthetic Organic Chemistry Methods