Role of the auxiliary ligand in determining the genotoxicity and mode of cell death of thiosemicarbazone Pd(<scp>ii</scp>) complexes
Ahmed M. Mansour, Rabaa M. Khaled, Krzysztof Radacki, Mona A.M. Abo-Zeid, Ola R. Shehab, G. Mostafa, Essam A. Ali, Mahmoud T. Abo‐Elfadl
Abstract
of each complex, the complex-treated cells exhibited considerable genotoxicity when compared to the corresponding non-treated control especially in the case of isothiocyanate and tetrazole-thiolato complexes.
Topics & Concepts
SemicarbazoneLigand (biochemistry)GenotoxicityChemistryChelationCytotoxicityStereochemistryIonMedicinal chemistryIn vitroReceptorInorganic chemistryOrganic chemistryBiochemistryToxicityMetal complexes synthesis and propertiesComputational Drug Discovery MethodsSynthesis and Characterization of Heterocyclic Compounds