Diosmetin and Its Glycoside, Diosmin, Improve Atopic Dermatitis- Like Lesions in 2,4-Dinitrochlorobenzene-Induced Murine Models
Sang-a Park, Sim-Kyu Bong, Jin Woo Lee, No-June Park, Yong-Soo Choi, Sang Moo Kim, Min Hye Yang, Yong Kee Kim, Su‐Nam Kim
Abstract
assay, only diosmetin, not diosmin, reduced the expression level of IL-4 mRNA in RBL-2H3 cells. Diosmin and diosmetine alleviated the altered epidermal thickness and immune cell infiltration in AD. Diosmin is considered effective in the cure of AD and skin inflammatory diseases by being converted into diosmetin in the body by pharmacokinetic metabolism. Thus, oral administration of diosmetin and diosmin might be a useful agent for the treatment of AD and cutaneous inflammatory diseases.
Topics & Concepts
Atopic dermatitisDiosminGlycosideMedicineDermatologyTraditional medicineBiologyBotanyPathologyAlternative medicineHesperidinDermatology and Skin DiseasesFood Allergy and Anaphylaxis ResearchContact Dermatitis and Allergies