Ru<sup>II</sup>-Complexes of heteroditopic chelating NHC ligands: effective catalysts for the β-alkylation of secondary alcohols and the synthesis of 2-alkylaminoquinoline derivatives following the dehydrogenative protocol
Vivek Singh, S. N. R. Donthireddy, Vipin K. Pandey, Arnab Rit
Abstract
H NMR and ESI-MS analyses validated the participation of a Ru-H species in the catalytic cycle. Remarkably, the present system displayed the highest Ru-based TON of 396 000 for the β-benzylation of 1-phenylethanol with a catalyst loading of 1 ppm (0.0001 mol%). Additionally, diverse 2-alkylaminoquinoline derivatives were synthesized in a one-pot manner from 2-aminobenzyl alcohol, 2-arylacetonitrile, and various primary alcohols.
Topics & Concepts
AlkylationCatalysisChelationChemistryLigand (biochemistry)Combinatorial chemistryMedicinal chemistryOrganic chemistryBiochemistryReceptorN-Heterocyclic Carbenes in Organic and Inorganic ChemistryAsymmetric Hydrogenation and CatalysisCatalytic Cross-Coupling Reactions