β-Cyclodextrin: a green supramolecular catalyst assisted eco-friendly one-pot three-component synthesis of biologically active substituted pyrrolidine-2-one
Subhankar Paul, Sharmistha Das, Bijeta Mitra, Gyan Chandra Pariyar, Pranab Ghosh
Abstract
A green, novel and eco-efficient synthetic route towards the synthesis of highly substituted bio-active pyrrolidine-2-one derivatives was demonstrated using β-cyclodextrin, a water-soluble supramolecular solid as a green and eco-benign catalyst at room temperature under water-ethanol solvent medium. The exploration of the green catalyst β-cyclodextrin for the metal-free one-pot three-component synthesis of a wide range of highly functionalized bio-active heterocyclic pyrrolidine-2-one moieties from easily available aldehydes and amines explains the superiority and uniqueness of this protocol.
Topics & Concepts
PyrrolidineCatalysisChemistryCyclodextrinSupramolecular chemistrySolventGreen chemistryCombinatorial chemistrySupramolecular catalysisOrganic chemistryEnvironmentally friendlyMoleculeReaction mechanismBiologyEcologyMulticomponent Synthesis of HeterocyclesChemical Synthesis and ReactionsChemistry and Chemical Engineering