Early-life pulmonary viral infection leads to long-term functional and lower airway structural changes in the lungs
Carrie‐Anne Malinczak, Wendy Fonseca, Steven Hrycaj, Susan B. Morris, Andrew J. Rasky, Kazuma Yagi, Deneen M. Wellik, Steven F. Ziegler, Rachel L. Zemans, Nicholas W. Lukacs
2024American Journal of Physiology-Lung Cellular and Molecular Physiology25 citationsDOIOpen Access PDF
Abstract
These studies outline a novel finding that early-life respiratory virus infection can alter lung structure and function long-term. Importantly, the data also indicate that there are critical links between inflammatory responses and subsequent events that produce a more severe pathogenic response later in life. The findings provide additional data to support that early-life infections during lung development can alter the trajectory of airway function.
Topics & Concepts
AirwayTerm (time)Viral infectionImmunologyMedicineVirologyBiologyVirusPhysicsSurgeryQuantum mechanicsRespiratory viral infections researchNeonatal Respiratory Health ResearchRespiratory Support and Mechanisms