A two-photon responsive naphthyl tagged <i>p</i>-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring
Amit Kumar Singh, Moumita Kundu, Samrat Roy, Biswajit Roy, Sk. Sheriff Shah, Asha V. Nair, Bipul Pal, Mahitosh Mondal, N. D. Pradeep Singh
Abstract
We report a two-photon responsive drug delivery system (DDS), namely, p-hydroxyphenacyl-naphthalene-chlorambucil (pHP-Naph-Cbl), having a two-photon absorption (TPA) cross-section of ≥20 GM in the phototherapeutic window (700 nm). Our DDS exhibited both AIE and ESIPT phenomena, which were utilized for the real-time monitoring of anti-cancer drug release.
Topics & Concepts
Drug deliveryDrugTwo-photon excitation microscopyChemistryAbsorption (acoustics)NanotechnologyFluorescenceMaterials scienceMedicinePharmacologyOpticsPhysicsComposite materialPhotochromic and Fluorescence ChemistryNonlinear Optical Materials StudiesPorphyrin and Phthalocyanine Chemistry