Microsatellite Instability and Mismatch Repair Deficiency Define a Distinct Subset of Lung Cancers Characterized by Smoking Exposure, High Tumor Mutational Burden, and Recurrent Somatic MLH1 Inactivation
Soo‐Ryum Yang, Erika Gedvilaite, Ryan Ptashkin, Jason C. Chang, John Ziegler, Douglas A. Mata, Liliana Villafania, Khédoudja Nafa, Jaclyn F. Hechtman, Ryma Benayed, Ahmet Zehir, Jamal Benhamida, Maria E. Arcila, Diana Mandelker, Charles M. Rudin, Paul K. Paik, Alexander Drilon, Adam J. Schoenfeld, Marc Ladanyi
Topics & Concepts
Microsatellite instabilityMLH1MSH2MedicinePMS2Lynch syndromeDNA mismatch repairGermline mutationLung cancerOncologyCancer researchInternal medicineMSH6MutationCancerBiologyGeneticsMicrosatelliteGeneColorectal cancerAlleleGenetic factors in colorectal cancerCancer Immunotherapy and BiomarkersLung Cancer Treatments and Mutations