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Microsatellite Instability and Mismatch Repair Deficiency Define a Distinct Subset of Lung Cancers Characterized by Smoking Exposure, High Tumor Mutational Burden, and Recurrent Somatic MLH1 Inactivation

Soo‐Ryum Yang, Erika Gedvilaite, Ryan Ptashkin, Jason C. Chang, John Ziegler, Douglas A. Mata, Liliana Villafania, Khédoudja Nafa, Jaclyn F. Hechtman, Ryma Benayed, Ahmet Zehir, Jamal Benhamida, Maria E. Arcila, Diana Mandelker, Charles M. Rudin, Paul K. Paik, Alexander Drilon, Adam J. Schoenfeld, Marc Ladanyi

2023Journal of Thoracic Oncology31 citationsDOIOpen Access PDF

Topics & Concepts

Microsatellite instabilityMLH1MSH2MedicinePMS2Lynch syndromeDNA mismatch repairGermline mutationLung cancerOncologyCancer researchInternal medicineMSH6MutationCancerBiologyGeneticsMicrosatelliteGeneColorectal cancerAlleleGenetic factors in colorectal cancerCancer Immunotherapy and BiomarkersLung Cancer Treatments and Mutations
Microsatellite Instability and Mismatch Repair Deficiency Define a Distinct Subset of Lung Cancers Characterized by Smoking Exposure, High Tumor Mutational Burden, and Recurrent Somatic MLH1 Inactivation | Litcius