Lactate Dehydrogenase: The Beacon of Hope?
Anitha Krishnan Pandarathodiyil, Anand Ramanathan, Ranjana Garg, Jennifer Geraldine Doss, Fazliny Binti Abd Rahman, Wan Maria Nabillah Ghani, Srinivas Prasad Vijayan
Abstract
Lactate dehydrogenase enzyme (LDH) helps in the conversion of glucose into pyruvic acid during aerobic glycolysis and is found in the cytoplasm of most cells in the human body. When oxidative stress occurs in the body, LDH may be released extracellularly and its level is usually indicative of the severity of tissue damage. LDH has proved to be an inestimably resourceful marker in early prediction of serious diseases involving extensive tissue or cellular damage. This short communication explores the potential of LDH as a salivary biomarker of cell injury and death.
Topics & Concepts
Lactate dehydrogenaseGlycolysisBiomarkerOxidative stressCytoplasmBiochemistryEnzymeAnaerobic glycolysisDehydrogenasePyruvic acidCellCell damageChemistryPathologyBiologyMedicineSalivary Gland Disorders and FunctionsCancer, Hypoxia, and MetabolismS100 Proteins and Annexins