Aspergillus flavus Infections in Children With Leukemia Despite Liposomal Amphotericin-B Prophylaxis
Nadja Hawwa Vissing, Birgitte Lausen, Marianne Hoffmann, Bodil Als‐Nielsen, Kjeld Schmiegelow, Jannik Helweg‐Larsen, Maiken Cavling Arendrup, Ulrikka Nygaard
Abstract
Liposomal amphotericin-B (L-AmB) prophylaxis is used in children with leukemia when azoles are contraindicated, but its effect is debated. We reviewed cases of invasive aspergillosis despite L-AmB 2.5 mg/kg twice weekly in children with high-risk leukemia during 2012-2019. Ten (16%) of 62 children had proven or probable aspergillosis. Thus, L-AmB prophylaxis offered insufficient protection for Aspergillus, in particular for Aspergillus flavus.
Topics & Concepts
AspergillosisAspergillus flavusAmphotericin BMedicineAspergillusLeukemiaMicrobiologyInternal medicineImmunologyDermatologyAntifungalBiologyAntifungal resistance and susceptibilityFungal Infections and StudiesNail Diseases and Treatments