Photochemical selective difluoroalkylation reactions of bicyclobutanes: direct sustainable pathways to functionalized bioisosteres for drug discovery
Yunxin Duan, Yerong Xu, Yunzhe Li, Lin Mao, Jianquan Feng, Jianquan Feng, Ruyue Zhang, Weifang Tang, Tao Lu, Yadong Chen, Jie Feng, Jie Feng
Abstract
Photochemical solvent-controlled difluoromethylation and bromo-difluoromethylation reactions of bicyclobutanes are described. The method provides efficient pathways to obtain difluoroalkyl functionalized bioisosteres for drug discovery.
Topics & Concepts
Drug discoveryChemistryCombinatorial chemistryDrugPharmacologyBiologyBiochemistryFluorine in Organic ChemistryClick Chemistry and ApplicationsChemical Synthesis and Analysis