Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis
Shengtian Cao, Xinye Yang, Zheng Zhang, Junwen Wu, Bo Chi, Hong Chen, Jianghong Yu, Shanshan Feng, Yulin Xu, Jing Li, Ying‐Jun Zhang, Xiaojun Wang, Yan Wang
Topics & Concepts
Farnesoid X receptorObeticholic acidSteatohepatitisChemistryPharmacologyBile acidAgonistFatty liverCirrhosisNuclear receptorInternal medicineReceptorMedicineBiochemistryDiseaseTranscription factorGeneLiver Disease Diagnosis and TreatmentDrug Transport and Resistance MechanismsHepatitis B Virus Studies