NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis
Rui Zhan, Xia Meng, Dongping Tian, Jie Xu, Hongtu Cui, Jialei Yang, Yangkai Xu, Mingming Shi, Jing Xue, Weiwei Yu, Gaofei Hu, Ke Li, Xiaoxiao Ge, Qi Zhang, Mingming Zhao, Jianyong Du, Xin Guo, Wenli Xu, Yang Gao, Changyu Yao, Fan Chen, Yue Chen, Wenxin Shan, Yujie Zhu, Ji Liang, Bing Pan, Yan Yu, Wenguang Li, Xuyang Zhao, Qihua He, Xiaohui Liu, Yue Huang, Shengyou Liao, Bin Zhou, Dehua Chui, Y. Eugene Chen, Zheng Sun, Erdan Dong, Yongjun Wang, Lemin Zheng
Topics & Concepts
PARP1NAD+ kinaseNicotinamide mononucleotidePoly ADP ribose polymeraseSIRT3NeurodegenerationSirtuinNeuroprotectionSirtuin 1OlaparibCell biologyBiologyBlood–brain barrierApolipoprotein ENeuroscienceNicotinamide adenine dinucleotidePharmacologyBiochemistryInternal medicineMedicinePolymeraseCentral nervous systemDownregulation and upregulationEnzymeGeneDiseaseConnexins and lens biologyBarrier Structure and Function StudiesPARP inhibition in cancer therapy