Redox‐Neutral Tetrafluoroethylation of Aryl Alkynes with 1,1,2,2‐Tetrafluoroethane Sulfonic Acid Leading to α‐Tetrafluoroethylated Acetophenones
Takuji Kawamoto, Kohki Noguchi, Ryotaro Takata, Rio Sasaki, Hiroshi Matsubara, Akio Kamimura
Abstract
The redox-neutral tetrafluoroethylation of alkynes with 1,1,2,2-tetrafluroroethanesulfonic acid (TFESA) and azobis(isobutyronitrile) (AIBN) proceeds via the formation of vinyl tetrafluoroethanesulfonates followed by a radical tetrafluoroethylation. Experimental and theoretical results support an intermolecular reaction.
Topics & Concepts
ChemistryRedoxArylIntermolecular forceSulfonic acidPolymer chemistryPhotochemistryMedicinal chemistryOrganic chemistryMoleculeAlkylFluorine in Organic ChemistrySulfur-Based Synthesis Techniques