Adenovirus-IL-10 relieves chronic rejection after mouse heart transplantation by inhibiting miR-155 and activating SOCS5
Gangcheng Kong, Yuqi Chen, Zongtao Liu, Yixuan Wang, Huadong Li, Chao Guo
Abstract
IL-10 downregulated miR-155 and activated SOCS5, thereby promoting macrophage M2 polarization to relieve chronic rejection after heart transplantation.
Topics & Concepts
CD163TransplantationApoptosisM2 MacrophageInflammationFibrosisImmunologyMacrophageMedicinePhagocytosisCD16CCL2BiologyImmune systemIn vitroInternal medicineCD8ChemokineCD3BiochemistryTransplantation: Methods and OutcomesRNA Interference and Gene DeliveryMicroRNA in disease regulation