Sputum Microbiome and Chronic Obstructive Pulmonary Disease in a Rural Ugandan Cohort of Well-Controlled HIV Infection
Alex Kayongo, Theda Ulrike Patricia Bartolomaeus, Till Birkner, Lajos Markó, Ulrike Löber, Edgar Kigozi, Carolyne Atugonza, Richard Munana, Denis Mawanda, Rogers Sekibira, Esther Uwimaana, Patricia Alupo, Robert Kalyesubula, Felix Knauf, Trishul Siddharthan, Bernard S. Bagaya, David Patrick Kateete, Moses Joloba, Nelson K. Sewankambo, Daudi Jjingo, Bruce Kirenga, William Checkley, Sofia K. Forslund
Abstract
Even with ART available, HIV-infected individuals are at high risk of suffering comorbidities, as shown by the high prevalence of noninfectious lung diseases in the HIV population. Recent studies have suggested a role for the respiratory microbiota in driving chronic lung inflammation.
Topics & Concepts
MedicineSputumMicrobiomeCOPDHuman immunodeficiency virus (HIV)ImmunologyPopulationCohortPulmonary diseaseLung infectionCohort studyLungObstructive lung diseaseInternal medicineBioinformaticsEnvironmental healthTuberculosisBiologyPathologyPneumocystis jirovecii pneumonia detection and treatmentChronic Obstructive Pulmonary Disease (COPD) ResearchHIV/AIDS Research and Interventions