NLRP3 blockade by MCC950 suppressed osteoclastogenesis via NF-κB/c-Fos/NFATc1 signal pathway and alleviated bone loss in diabetes mellitus
Guoping Cai, Xiaoting Song, Hua Luo, G. Dai, Honghao Zhang, Dengteng Jiang, Xinhuan Lei, Haixiao Chen, Liwei Zhang
Topics & Concepts
BlockadeDiabetes mellitusNF-κBSignal transductionReceptorType 2 Diabetes MellitusSignal pathwayEndocrinologyMedicineNFKB1Internal medicineChemistryPharmacologyBiologyCell biologyBiochemistryGeneTranscription factorInflammasome and immune disordersBone Metabolism and DiseasesMacrophage Migration Inhibitory Factor