An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia
Shinnosuke Suzuki, John R. McCarrey, Brian P. Hermann
Abstract
testes lacking intercellular bridges do not accumulate activated SSCs following mTORC1 inhibition, indicating that steady-state mTORC1 signaling drives activated SSCs to produce progenitor clones. These results are consistent with a model of SSC self-renewal dependent on interconversion between activated and quiescent SSCs, and mTORC1-dependent initiation of differentiation from SSCs to progenitor clones.
Topics & Concepts
Progenitor cellmTORC1BiologyCell biologyProgenitorStem cellSignal transductionProtein kinase BSperm and Testicular FunctionReproductive Biology and FertilityRenal and related cancers