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Design and synthesis of tri-substituted pyrimidine derivatives as bifunctional tumor immunotherapeutic agents targeting both A2A adenosine receptors and histone deacetylases

Ruiquan Liu, Wenwen Duan, Wenzhong Yan, Jinfeng Zhang, Jianjun Cheng

2023Chinese Chemical Letters10 citationsDOI

Topics & Concepts

ChemistryAdenosine receptorHistone deacetylasePharmacophoreHDAC1PyrimidineReceptorIn vitroAntagonistBifunctionalPharmacologyStereochemistryCancer researchHistoneBiochemistryMedicineCatalysisAgonistGeneAdenosine and Purinergic SignalingHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and Analysis
Design and synthesis of tri-substituted pyrimidine derivatives as bifunctional tumor immunotherapeutic agents targeting both A2A adenosine receptors and histone deacetylases | Litcius