Molecular and therapeutic insights of rapamycin: a multi-faceted drug from Streptomyces hygroscopicus
Sanjeev K. Ganesh, C. Subathra Devi
Topics & Concepts
PI3K/AKT/mTOR pathwayStreptomyces hygroscopicusDrug discoverySirolimusMechanistic target of rapamycinDrug developmentDrugBiologyComputational biologyPharmacologyDiscovery and development of mTOR inhibitorsDrug repositioningCytokine stormAutophagyBioinformaticsSignal transductionCoronavirus disease 2019 (COVID-19)MedicineStreptomycesBiochemistryGeneticsInfectious disease (medical specialty)BacteriaPathologyApoptosisDiseasePI3K/AKT/mTOR signaling in cancerCancer therapeutics and mechanismsEnzyme function and inhibition