Inclusion body myositis: an update
Nicolaas Anderson, Thomas E. Lloyd
Abstract
PURPOSE OF REVIEW: To review recent advances in our understanding of the epidemiology, pathophysiology, and management of inclusion body myositis (IBM). RECENT FINDINGS: Recent epidemiologic studies have highlighted the morbidity and mortality associated with IBM, including the impact of dysphagia. Multiomic analyses of IBM tissues have identified new pathogenic pathways and biomarkers for use in clinical trials. New diagnostic criteria and outcome measures have been proposed to improve clinical trial design. Ongoing clinical trials are targeting T cells and autophagy. SUMMARY: Improvements in our understanding of IBM pathogenesis are identifying new pathways and biomarkers that need validation in larger cohorts. Exercise remains the primary therapeutic modality available, and new treatment targets are needed.