<i>Helicobacter pylori</i> infection and other bacteria in pancreatic cancer and autoimmune pancreatitis
Lumír Kunovský, Petr Dítě, Petr Jabandžiev, Jiří Dolina, Jitka Vaculová, Martin Blaho, Martina Bojková, Jana Dvořáčková, Magdaléna Uvírová, Zdeněk Kala, Jan Trna
Abstract
, as a part of microbiome dysbiosis, also is viewed as a potential trigger of autoimmune inflammation of the pancreas. It is precisely these relationships (and associated equivocal conclusions) that constitute a center of attention among pancreatologists, immunologists and pathologists. In order to obtain clear and valid results, more studies on sufficiently large cohorts of patients are needed. The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research. Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer.