Selective Induction of Cellular Toxicity and Anti-tumor Efficacy by N-Methylpiperazinyl Diarylidenylpiperidone and its Pro-nitroxide Conjugate through ROS-mediated Mitochondrial Dysfunction and G2/M Cell-cycle Arrest in Human Pancreatic Cancer
Jesse M. Mast, John W. Hinds, Dan Tse, Katherine S. Axelrod, M. Lakshmi Kuppusamy, Maciej M. Kmieć, Balázs Bognár, Tamás Kálai, Periannan Kuppusamy
Topics & Concepts
Pancreatic cancerCancer researchApoptosisCell cycleCell cycle checkpointMedicineCancerPharmacologyChemistryInternal medicineBiochemistryCancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology ResearchDrug Transport and Resistance Mechanisms