Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds
Ricardo G. Teixeira, Dimas Carolina Belisario, Xavier Fontrodona, Isabel Romero, Ana Isabel Tomaz, M. Helena García, Chiara Riganti, Andreia Valente
Abstract
Ru compounds exhibit collateral sensitivity in cisplatin-resistant NSCLC and increase cisplatin activity by inhibiting efflux pumps.
Topics & Concepts
CisplatinRutheniumEffluxChemistryLung cancerCollateralCancer researchCombinatorial chemistryInternal medicineMedicineBiochemistryChemotherapyBusinessFinanceCatalysisMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsMetal-Organic Frameworks: Synthesis and Applications