Fe-Catalyzed Intramolecular B–H/C–H Dehydrogenative Coupling: Synthesis of Carborane-Fused Nitrogen Heterocycles
Yu Chen, Hairong Lyu, Yangjian Quan, Zuowei Xie
Abstract
We disclose herein the first example of iron-catalyzed regioselective intramolecular C-H/B-H dehydrogenative coupling, affording unprecedented C,B-substituted carborane-fused phenanthroline derivatives. The 8-aminoquinoline type auxiliaries not only serve as the bidentate directing groups but also ingeniously become the core part of the final products. The mechanistic hypothesis includes B-H activation, directing group rotation promoted by trans effect, C-H activation, and reductive elimination.
Topics & Concepts
Intramolecular forceChemistryCarboraneCatalysisNitrogenCoupling (piping)Combinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryMechanical engineeringEngineeringBoron Compounds in ChemistryRadiopharmaceutical Chemistry and ApplicationsOrthopedic Infections and Treatments