Heart-on-a-Chip Model with Integrated Extra- and Intracellular Bioelectronics for Monitoring Cardiac Electrophysiology under Acute Hypoxia
Haitao Liu, Olurotimi A. Bolonduro, Ning Hu, Jie Ju, Akshita A. Rao, Breanna M. Duffy, Zhaohui Huang, Lauren D. Black, Brian P. Timko
Abstract
channels that promote membrane repolarization. Significantly, both extra- and intracellular devices could be multiplexed, enabling mapping capabilities unachievable by other electrophysiological tools. Our platform represents a significant advance toward understanding electrophysiological responses to hypoxia and could be applicable to disease modeling and drug development.
Topics & Concepts
BioelectronicsElectrophysiologyHypoxia (environmental)IntracellularCardiac electrophysiologyExtracellularNeuroscienceBiologyChemistryCell biologyNanotechnologyMaterials scienceBiosensorOxygenOrganic chemistryNeuroscience and Neural EngineeringIon channel regulation and functionAdvanced Sensor and Energy Harvesting Materials