Protein S‐Palmitoylation: advances and challenges in studying a therapeutically important lipid modification
Alice Main, William Fuller
Abstract
The lipid post-translational modification S-palmitoylation is a vast developing field, with the modification itself and the enzymes that catalyse the reversible reaction implicated in a number of diseases. In this review, we discuss the past and recent advances in the experimental tools used in this field, including pharmacological tools, animal models and techniques to understand how palmitoylation controls protein localisation and function. Additionally, we discuss the obstacles to overcome in order to advance the field, particularly to the point at which modulating palmitoylation may be achieved as a therapeutic strategy.
Topics & Concepts
PalmitoylationPosttranslational modificationComputational biologyFunction (biology)Protein functionNeuroscienceBiologyCell biologyEnzymeBiochemistryCysteineGeneATP Synthase and ATPases ResearchLipid Membrane Structure and BehaviorProtein Kinase Regulation and GTPase Signaling