Autophagy-inhibiting biomimetic nanodrugs enhance photothermal therapy and boost antitumor immunity
Peiying Huang, Yin-Yin Zhu, Hao Zhong, Peiling Chen, Qun‐Ying Shi, Jiaoyu Chen, Jinmei Lai, Yingfeng Tu, Shuwen Liu, Li‐Han Liu
Abstract
. The ICGCQ@RCm NPs demonstrated tumor-targeting and imaging-guided autophagy inhibition-sensitized LTPTT using two Food and Drug Administration (FDA)-approved drugs, which have great potential for clinical application.
Topics & Concepts
Photothermal therapyAutophagyIndocyanine greenIn vivoCancer researchChemistryCancer cellImmunogenic cell deathMetastasisDrug deliveryIn vitroCancerPharmacologyMedicinePathologyApoptosisNanotechnologyBiologyMaterials scienceInternal medicineBiochemistryOrganic chemistryBiotechnologyNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseAutophagy in Disease and Therapy